Drug Side Effects Successfully Predicted By Computer Model (with Fast Stats on Drug Failure Rates)
Cost efficient way to develop safer compounds
A new set of computer models has successfully predicted negative side effects in hundreds of current drugs, based on the similarity between their chemical structures and those molecules known to cause side effects, according to a paper appearing online this week in the journal Nature. …
Drugs frequently interact with more than one target, with hundreds of these targets linked to the side effects of clinically used therapeutics. Focusing on 656 drugs that are currently prescribed, with known safety records or side effects, the team was able to predict such undesirable targets – and thus potential side effects – half of the time.
That’s a significant leap forward from previous work, which has never tackled hundreds of compounds at once, according to Brian Shoichet, PhD, a UCSF professor of pharmaceutical chemistry who was the joint advisor on the project alongside Laszlo Urban, MD, PhD, at Novartis.
As a result, it offers a possible new way for researchers to focus their efforts on developing the compounds that will be safest for patients, while potentially saving billions of dollars each year that goes into studying and developing drugs that fail. …
Drug Failure Rates
- Estimated cost of bringing a drug to market: $1.2 billion
- Only one in 5,000 drug candidates that enter preclinical testing ever reaches the market
- For every five drugs that start clinical trials, only one succeeds
- Of the 4,300 companies engaged in drug innovation, only 6% (261) have registered a new drug since 1950.
- Worldwide, the pharmaceutical industry spends $50 Billion per year on R&D, but produces only 21 new drugs per year (2008)
- Computer Model Successfully Predicts Drug Side Effects (InnovationToronto.com)
- The cost of Pharma R&D failure (scienceintelligence.wordpress.com)
- Computer model successfully predicts drug side effects (eurekalert.org)
- Assessing Drug Target Association Using Semantic Linked Data (ploscompbiol.org)
- Novartis predicts drug side effects with computers (fiercebiotechit.com)
- Side Effects of Cholesterol-Lowering Treatments (everydayhealth.com)
- Infographic: A Chart That Helps Predict Drug Side Effects (fastcodesign.com)
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