Health and Medical News and Resources

General interest items edited by Janice Flahiff

Taking A Predictive Approach To Identifying Adverse Drug Reactions

New mathematical method combines widely available data to potentially predict drug safety issues years earlier than currently possible

From the 21 December 2011 Boston Children’s Hospital news release

Boston, Mass. – In a move aimed at bolstering current systems for assessing and monitoring drug safety, researchers at Children’s Hospital Boston have created a new method that combines multiple forms of widely available data to predict adverse drug reactions. Unlike current approaches, which rely on detecting evidence of drug safety issues as they accumulate over time in clinical databases, this new method may be able to identify issues years in advance.

This study, led by Aurel Cami, PhD, and Ben Reis, PhD, of Children’s Hospital Boston’s Informatics Program (CHIP), appeared online December 21 in Science Translational Medicine.In a move aimed at bolstering current systems for assessing and monitoring drug safety, researchers at Children’s Hospital Boston have created a new method that combines multiple forms of widely available data to predict adverse drug reactions. Unlike current approaches, which rely on detecting evidence of drug safety issues as they accumulate over time in clinical databases, this new method may be able to identify issues years in advance.
This study, led by Aurel Cami, PhD, and Ben Reis, PhD, of Children’s Hospital Boston’s Informatics Program (CHIP), appeared online December 21 in Science Translational Medicine.

The safety of drugs in the market is currently assessed through a combination of adverse drug event (ADE) reporting and data mining tools designed to detect previously unrecognized drug-ADEs relationships. While generally effective, these methods may not be able to flag the presence of certain types of ADEs until patients have been on the drug for some time.

Because of these limitations, it can take years before physicians and regulators accumulate enough data to recognize serious safety problems with a particular drug and take appropriate action.

To help address these delays and the public health risks associated with them, Reis and Cami set out to create a mathematical model for predicting drug-ADE relationships that might likely appear within a few years of a drug’s entry into the market. …

Read the entire news article

Related Resources

  • MedWatch: The FDA Safety Information and Adverse Event Reporting Program (jflahiff.wordpress.com)

    Some examples of good drug information Web sites

    Drugs, Supplements, and Herbal Information (from a MedlinePlus page)

    Prescription and over-the-counter medication information contains answers to many general questions including topics as what a drug is used for, precautions, side effects, dietary instructions, and overdoses. From the American Society of Health System Pharmacists

    Herb and supplement information includes information on uses based on scientific evidence as well as safety and potential interactions with drugs, herbs, and supplements. From Natural Standard, an independent group of researchers and clinicians.


    Drugs and Supplements (sponsored by the Mayo Clinic)

    Somewhat lengthy drug and over-the-counter medicationinformation with these sections: description, before using, proper use, precautions and side effects. From Micromedex, a trusted source of healthcare information for health professionals. 

    Herb and supplement information includes information on uses based on scientific evidence as well as safety and potential interactions with drugs, herbs, and supplements. From Natural Standard, an independent group of researchers and clinicians.

    Drug Information Portal

    A good central source of drug information by the US government (the National Institutes of Health). It links you to information on over 12,000 drugs from trusted consumer drug information sources, the US Food and Drug Information, and LactMed (summary of effects on breastfeeding), It also gives any summaries from medical and toxicological articles (however, some whole articles may not be for free on the Internet).

     

January 2, 2012 - Posted by | Medical and Health Research News | ,

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