Health and Medical News and Resources

General interest items edited by Janice Flahiff

Bioorthogonal Chemistry – Making Drugs Inside Patients – And More

From the 27 March 2012 article at Medical News Today

The traditional way of making medicines from ingredients mixed together in a factory may be joined by a new approach in which doctors administer the ingredients for a medicine separately to patients, and the ingredients combine to produce the medicine inside patients’ bodies.

That’s one promise from an emerging new field of chemistry, according to the scientist who founded it barely a decade ago. Carolyn Bertozzi, Ph.D., spoke on the topic – bioorthogonal chemistry – delivering the latest Kavli Foundation Innovations in Chemistry Lecture at the 243rd National Meeting & Exposition of the American Chemical Society (ACS).

Bertozzi explained that the techniques of bioorthogonal chemistry may fundamentally change the nature of drug development and diagnosis of disease, so that the active ingredients for medicines and substances to image diseased tissue are produced inside patients.

“Suppose a drug doesn’t reach diseased tissue in concentrations high enough to work,” Bertozzi said, citing one example of the potential of the new chemistry. “Maybe it is an oral drug that doesn’t get absorbed very well into the blood through the stomach. You can imagine a scenario in which doctors administer two parts of the molecule that makes up the drug. …

March 28, 2012 - Posted by | Medical and Health Research News | ,

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