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[News release] Healing plants inspire new compounds for psychiatric drugs

Healing plants inspire new compounds for psychiatric drugs

From the 11 May 2015 Northwestern University news release

Scientists look to healers in Nigeria to develop better therapies for mental disorders

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May 11, 2015 | by Erin Spain

EVANSTON, Ill. — Treatments used by traditional healers in Nigeria have inspired scientists at Northwestern University to synthesize four new chemical compounds that could one day lead to better therapies for people with psychiatric disorders.

In a paper published online in the journal Angewandte Chemie International Edition, the scientists detail how they created these natural compounds by completing the first total syntheses of two indole alkaloids — alstonine and serpentine. These alkaloids, found in various plant species used by healers in Nigeria to treat people with conditions such as schizophrenia and bipolar disorder, have antipsychotic properties that have potential to improve mental disorder treatments.

The current drugs used for schizophrenia effectively treat delusions and hallucinations but are only partially effective for cognitive impairment. Early experimental research of these new compounds in animal models shows promise in improving cognitive impairment, the Northwestern scientists said.

Traditional healers boil these special plants and produce an extract that they administer to people with symptoms of mental illness. However, this extract isn’t pure, and it contains other compounds and materials that may not be beneficial to people with mental disorders.

“Nature did not intend this plant to produce an antipsychotic drug on its own,” Meltzer said.

The collaborative work to create the compounds took place in the Center for Molecular Innovation and Drug Discovery (CMIDD) at Northwestern, using high-level purification resources and state-of-the-art research instrumentation and equipment. Scheidt is the director of CMIDD.

Through an efficient and stereo-selective synthesis, Scheidt and his team created four separate but related natural products. Now a template exists to continue making these compounds as needed for future studies and ultimately for use in clinical drug trials.

“We can make multi-gram quantities of any of the compounds we want,” Scheidt said. “We built the assembly line and are now uniquely positioned to explore their potential.”

Meltzer is already using these compounds in animal studies in his lab to better understand how they affect brain biology and chemistry in the schizophrenia disease model. Early results from his lab show that the compounds may increase the ability of other antipsychotic drugs to improve cognitive impairment.

Other study authors are Dr. Ashkaan Younai and Bi-Shun Zeng of Northwestern University. This study was supported the Chemistry of Life Processes Institute at Northwestern in the form of an Innovators Grant and the Weisman Family Foundation.

– See more at: http://www.northwestern.edu/newscenter/stories/2015/05/healing-plants-inspire-new-compounds-for-psychiatric-drugs.html#sthash.pHX8AWsh.dpuf

– See more at: http://www.northwestern.edu/newscenter/stories/2015/05/healing-plants-inspire-new-compounds-for-psychiatric-drugs.html#sthash.pHX8AWsh.dpuf

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May 18, 2015 - Posted by | Medical and Health Research News, Psychiatry | , , , , , ,

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