Health and Medical News and Resources

General interest items edited by Janice Flahiff

Some ‘Inert’ Drug Ingredients May Be Biologically Active

Comprehensive Laboratory Study Flags Drug Components in Need of More Rigorous Review

The active ingredients in a drug are an extremely small part of the pill, liquid, or injectable, However the inert ingredients in drugs are not just “fillers” so that a pill is easy to handle. They” can be composed of ingredients including preservatives, dyes, antimicrobials and other compounds known as excipients**. These ingredients play critical roles in making sure a drug’s active ingredient is delivered safely and effectively, as well as conferring important qualities like shelf stability and the ability to quickly distinguish pills by color.”

The excipients have been generally been classified by scientists as nontoxic and biologically inactive. Some patients have described side effects from these excipients. A USCF team decided to study if indeed certain excipients are not as biologically inactive as thought. These studies will go a long way in deducing if a person is having side effects from the drug or added ingredients.

So far the team “the researchers have now systematically screened 3,296 excipients contained in the inactive ingredient database, and identified 38 excipient molecules that interact with 134 important human enzymes and receptors.”

Future research will expand on these hypothetical findings and test using animal models.

**Excipients are crucial to drug delivery within the body. Generally, an excipient has no medicinal properties. Its standard purpose is to streamline the manufacture of the drug product and ultimately facilitate physiological absorption of the drug. Excipients might aid in lubricity, flowability, disintegration, taste and may confer some form of antimicrobial function. Selecting the appropriate excipient to support the design of your pharmaceutical formulation is an important step in the drug manufacturing process. From Pharmaceutical Excipients

Read the entire summary here.

July 24, 2020 - Posted by | Consumer Health, Consumer Safety, Health News Items | , , ,

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