Health and Medical News and Resources

General interest items edited by Janice Flahiff

Study reveals major shift in how eczema develops

Study reveals major shift in how eczema develops
Not 1, but 2 skin barriers influential in most common skin disease

From the December 17, 2010 Eureka news release

Like a fence or barricade intended to stop unwanted intruders, the skin serves as a barrier protecting the body from the hundreds of allergens, irritants, pollutants and microbes people come in contact with every day. In patients with eczema, or atopic dermatitis, the most common inflammatory human skin disease, the skin barrier is leaky, allowing intruders – pollen, mold, pet dander, dust mites and others – to be sensed by the skin and subsequently wreak havoc on the immune system.

While the upper-most layer of the skin – the stratum corneum – has been pinned as the culprit in previous research, a new study published today in the Journal of Allergy and Clinical Immunology *** found that a second skin barrier structure, consisting of cell-to-cell connections known as tight junctions, is also faulty in eczema patients and likely plays a role in the development of the disease. Tightening both leaky barriers may be an effective treatment strategy for eczema patients, who often have limited options to temper the disease.

“Over the past five years, disruption of the skin barrier has become a central hypothesis to explain the development of eczema,” said Lisa Beck, M.D., lead study author and associate professor in the Department of Dermatology at the University of Rochester Medical Center. “Our findings challenge the belief that the top layer of the skin or stratum corneum is the sole barrier structure: It suggests that both the stratum corneum and tight junctions need to be defective to jumpstart the disease.”

Currently, there are no treatments that target skin barrier dysfunction in eczema. To treat eczema, which causes dry, red, itchy skin, physicians typically prescribe anti-inflammatory drugs, like prednisone, and a variety of topical anti-inflammatory creams and ointments. But, modest benefit, negative side effects and cost concerns associated with these therapies leave patients and doctors eagerly awaiting new alternatives.

A few related eczema items

  • Eczema (MedlinePlus) has links to overviews, disease management articles, and more
  • Dermatitis, Atopic (eMedicine) is written for physicians, article is free, however one must register to view it
  • Eczema(Atopic Dermatitis) is written for the general public, it has thorough coverage on on causes, treatments, support groups, exams/tests, prevention, follow-up, and more

 

***For suggestions on how to get this article for free or at low cost, click here.

December 18, 2010 Posted by | Consumer Health, Educational Resources (High School/Early College(, Finding Aids/Directories, Health Education (General Public), Health News Items | , , , | Leave a comment

Farm Environment, Cats Help Kids Avoid Skin Disease & Related Article (Growing Up on Farm Strengthens Immune System)

Farm Environment, Cats Help Kids Avoid Skin Disease

HealthDay news image

European researchers report rural living less likely to lead to atopic dermatitis for infants

Childhood exposure to germs in the environment strengthens their immune system, according to current scientific evidence. (See  Immune System (http://www.niaid.nih.gov/topics/immuneSystem/Pages/immunity.aspx) by the National Institute of Allergy and Infectious Diseases [NIAID])

Now it seems that the environment not only confers immunity through not only interacting with a child’s immune system after birth, but before birth.

Excerpts from a recent Health Day news article by Robert Preidt

WEDNESDAY, Dec. 8 (HealthDay News) — The children of mothers who were around farm animals and cats during pregnancy are less likely to develop atopic dermatitis in their first two years of life, new European research shows.

Atopic dermatitis (also called atopic eczema) is a chronic and painful inflammation of the skin that frequently occurs in childhood. The condition affects up to 20 percent of children in industrialized countries and is one of the most common childhood skin diseases….

….Along with the first finding, the researchers also identified two genes associated with a child’s reduced risk of developing atopic dermatitis in the first two years of life.

The findings support the theory that a gene-environment interaction with a child’s developing immune system influences the development of atopic dermatitis, said the researchers.

The study appears in the Journal of Allergy & Clinical Immunology.***
[The abstract of the article may be found here]

Previous research has found that allergies are less likely in children who grow up on farms and whose mothers lived on farms during their pregnancy.

SOURCE: Journal of Allergy & Clinical Immunology, news release, Dec. 2, 2010

Click here for suggestions on how to get the full text of the article

 

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Growing Up On A Farm Directly Affects Regulation Of The Immune System

From the 9 February 2012 Medical News Today article

Immunological diseases, such as eczemaand asthma, are on the increase in westernised society and represent a major challenge for 21st century medicine. A new study has shown, for the first time, that growing up on a farm directly affects the regulation of the immune system and causes a reduction in the immunological responses to food proteins. …

…Dr Marie Lewis, Research Associate in Infection and Immunity at the School of Veterinary Sciences, who led the research, said: “Many large-scale epidemiological studies have suggested that growing up on a farm is linked to a reduced likelihood of developing allergic disease. However, until now, it has not been possible to demonstrate direct cause and effect: does the farm environment actively protect against allergies, or are allergy-prone families unlikely to live on farms?” ,,,

 


December 12, 2010 Posted by | Consumer Health | , , , , , , , , , | 2 Comments

   

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