Health and Medical News and Resources

General interest items edited by Janice Flahiff

[Press release] New nanodevice defeats drug resistance

New nanodevice defeats drug resistance 

From the 3 March 2015 MIT press release

Tiny particles embedded in gel can turn off drug-resistance genes, then release cancer drugs.

Chemotherapy often shrinks tumors at first, but as cancer cells become resistant to drug treatment, tumors can grow back. A new nanodevice developed by MIT researchers can help overcome that by first blocking the gene that confers drug resistance, then launching a new chemotherapy attack against the disarmed tumors.

The device, which consists of gold nanoparticles embedded in a hydrogel that can be injected or implanted at a tumor site, could also be used more broadly to disrupt any gene involved in cancer.

“You can target any genetic marker and deliver a drug, including those that don’t necessarily involve drug-resistance pathways. It’s a universal platform for dual therapy,” says Natalie Artzi, a research scientist at MIT’s Institute for Medical Engineering and Science (IMES), an assistant professor at Harvard Medical School, and senior author of a paper describing the device in the Proceedings of the National Academy of Sciences the week of March 2.

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March 7, 2015 Posted by | Medical and Health Research News | , , , , , , | Leave a comment

[Press release] New possibilities for curing cancer

From the 17 February 2015 Concordia University press release

A Concordia study has unveiled the massive potential of a natural chemical
Lithocholic acid, a bile acid produced in the liver, is particularly effective in killing cancer cells.
Lithocholic acid, a bile acid produced in the liver, is particularly effective in killing cancer cells.

Montreal, February 17, 2015 — Where can you find the next important weapon in the fight against cancer? Just do a little navel-gazing. New research from Concordia confirms that a tool for keeping the most common forms of cancer at bay could be in your gut.

In a report published in the International Journal of Molecular Sciences, Vladimir Titorenko, a professor of biology at Concordia, and his colleagues show that lithocholic acid, a bile acid produced in the liver, is particularly effective in killing cancer cells.

For the study, the research team tested thousands of chemicals found in the body with the help of a robot and discovered more than 20 that could delay the aging process, something inevitably linked to cancer.

Most effective was lithocholic acid. When entering a cancer cell, the acid goes to “energy factories” called mitochondria and then sends molecular signals that lead to the cells’ demise.

February 19, 2015 Posted by | Medical and Health Research News | , , , , | Leave a comment

   

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