A Threat to Male Fertility – NYTimes.com

A Threat to Male Fertility – NYTimes.com.

 

“Phthalates belong to a group of industrial compounds known as endocrine disruptors because they interfere with the endocrine system, which governs the production and distribution of hormones in the body. The chemicals have been implicated in a range of health problems, including birth defects, cancers and diabetes.

But it is their effect on the human reproductive system that hasmost worried researchers. A growing body of work over the last two decades suggests that phthalates can rewire the male reproductive system, interfering with the operation of androgenic hormones, such as testosterone, that play key roles in male development. That mechanism, some experts believe, explains findings that link phthalate exposure to changes in everything from testicular development to sperm quality.”

“There are different kinds of phthalates complicating the picture; some seem to have a much larger effect than others. And these are far from the only factors, chemical and otherwise, that influence human fertility. Dr. Buck Louis’s group is looking at a broad range of industrial compounds, including heavy metals like lead and cadmium, that tend to accumulate in the body.

Phthalates, by contrast, tend to be metabolized within a few hours. Their impact would not be so profound if it were not that people are constantly exposed from multiple sources.

These include not only cosmetics and plastics, but also packaging, textiles, detergents and other household products. Phthalates are found in the tubing used in hospitals to deliver medications; in water flowing through PVC pipes; enteric coatings on pills, including some aspirin; materials used to create time-release capsules; and countless other products. In 2008, the government banned them in children’s toys, and the European Union is also moving forward on restrictions.

“The W.H.O. called them ‘pseudopersistent’ in one report,” Dr. Woodruff said, because continued exposure keeps phthalates in the body. But here’s the silver lining: the transient nature of these compounds also means that consumers can take fairly simple measures to reduce their phthalate levels.

One is to read the labels on cosmetics and other personal care products and to choose those without phthalates. Another is to be cautious with plastic food containers, and to avoid using them to heat food and drink, as the phthalates in them may get transferred to what you consume.

“These compounds leach from plastics,” Dr. Buck Louis said. “You can switch to glass for drinking. You can cook your frozen dinners on paper plates.”

Studies have shown that these kinds of actions do make a difference; experiments have found measurably lower levels within several days in people who make these changes.

“Lifestyle has an important place here,” said Dr. Buck Louis.”

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Interacting Risks – endocrine effects of a compound used in many antibacterial bar soaps

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• Relative Risk, One Result at a Time -Evidence mounts for endocrine effects of a compound used in many antibacterial bar soaps by Anna Lena Phillips at American ScientistWhy are endocrine-disrupting antibacterials still on the shelves?(sfgate.com)
• Phthalates and BPA: Of Mice and Men (sciencebasedmedicine.org)
• TOXMAP: Learn about toxic chemicals used in hydraulic fracturing (jflahiff.wordpress.com)
• New Way to Assess Risk from Chemicals (InnovationToronto.com)
• Environmental Toxins (education.com)

Related Resources

As the article notes, there are studies of the effects and hazards of single chemicals, but not many on chemical interactions

Here are a few free reputable resources on chemical hazards
— All (and more!) available at Toxnet (US National Library of Medicine)

• Household Products – This database links over 8,000 consumer brands to health effects from Material Safety Data Sheets (MSDS) provided by the manufacturers and allows scientists and consumers to research products based on chemical ingredients.
• Toxline – Extensive array of references to literature on biochemical, pharmacological, physiological, and toxicological effects of drugs and other chemicals.
• LactMed – A peer-reviewed and fully referenced database of drugs to which breastfeeding mothers may be exposed. Among the data included are maternal and infant levels of drugs, possible effects on breastfed infants and on lactation, and alternate drugs to consider.
• TOXMAP – Environmental Health e-Maps. Geographic representation of TRI data with links to other TOXNET resources.

Upstream

From American Scientist:

When research suggests that a single chemical may cause harm, public concern rises, as it has for the plastic additive bisphenol A (BPA) in recent years. But many more of the 83,000 or so humanmade chemicals used in the United States receive little attention. The possible effects of chemicals in combination get still less scrutiny, even though the potential that some chemicals will interact is high, given their numbers.

This may be due in part to the staggering amount of work required to discern those effects. It would be a very difficult task to keep up with research on all of these substances, much less evaluate their relative risk as new results appear. The U.S. Environmental Protection Agency (EPA) has put considerable effort into this under the Toxic Substances Control Act, but the Act has not been updated since its passage in 1976 and excludes many substances…

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