[Press release] Researchers have cracked a code that governs infections by a major group of viruses including the common cold and polio

From the 5 February 2015 University of Leeds press release

 

Researchers have cracked a code that governs infections by a major group of viruses including the common cold and polio.

Until now, scientists had not noticed the code, which had been hidden in plain sight in the sequence of the ribonucleic acid (RNA) that makes up this type of viral genome.

But a paper published in the Proceedings of the National Academy of Sciences (PNAS) Early Edition by a group from the University of Leeds and University of York unlocks its meaning and demonstrates that jamming the code can disrupt virus assembly. Stopping a virus assembling can stop it functioning and therefore prevent disease.

Professor Peter Stockley, Professor of Biological Chemistry in the University of Leeds’Faculty of Biological Sciences, who led the study, said: “If you think of this as molecular warfare, these are the encrypted signals that allow a virus to deploy itself effectively.

“Now, for this whole class of viruses, we have found the ‘Enigma machine’—the coding system that was hiding these signals from us. We have shown that not only can we read these messages but we can jam them and stop the virus’ deployment.”

Single-stranded RNA viruses are the simplest type of virus and were probably one of the earliest to evolve. However, they are still among the most potent and damaging of infectious pathogens.

Rhinovirus (which causes the common cold) accounts for more infections every year than all other infectious agents put together (about 1 billion cases), while emergent infections such as chikungunya and tick-borne encephalitis are from the same ancient family.

Other single-stranded RNA viruses include the hepatitis C virus, HIV and the winter vomiting bug norovirus.

This breakthrough was the result of three stages of research:

• In 2012, researchers at the University of Leeds published the first observations at a single-molecule level of how the core of a single-stranded RNA virus packs itself into its outer shell—a remarkable process because the core must first be correctly folded to fit into the protective viral protein coat. The viruses solve this fiendish problem in milliseconds. The next challenge for researchers was to find out how the viruses did this.

• University of York mathematicians Dr Eric Dykeman and Professor Reidun Twarock, working with the Leeds group, then devised mathematical algorithms to crack the code governing the process and built computer-based models of the coding system.

• In this latest study, the two groups have unlocked the code. The group used single-molecule fluorescence spectroscopy to watch the codes being used by the satellite tobacco necrosis virus, a single stranded RNA plant virus.

Read the entire article here

 

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Hand Sanitizers May Actually Cause Outbreaks Of Norovirus

From the 15 August 2011 Health News Today article

New research has found that hand sanitizers are not as effective as soap and water in health care settings at preventing viral outbreaks. In fact, they may even be responsible for outbreaks of seriously contagious viruses. As a common alternative to using soap and water, hand sanitizers are often regarded as being the most efficient way to cleanse hands.

Read entire news article

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The 10 Pathogen-Food Combinations With the Greatest Burden on Public Health

From Ranking the Risks : The 10 Pathogen-Food Combinations With the Greatest Burden on Public Health

Thursday, April 28, 2011 

GAINESVILLE, Fla. – Researchers at the University of FloridaEmerging Pathogens Institute have identified the Top 10 riskiest combinations of foods and disease-causing microorganisms, providing an important tool for food safety officials charged with protecting consumers from these costly and potentially life-threatening bugs.

The report, “Ranking the Risks: The 10 Pathogen-Food Combinations with the Greatest Burden on Public Health,” lists the number of illnesses, costs, and overall public health burden of specific microbes in particular types of food –such as Salmonella in poultry and Listeria in deli meat. This is the first comprehensive ranking of pathogen-food combinations that has been computed for the United States.

Millions of Americans get food poisoning each year and thousands die. Federal agencies such as the Food and Drug Administration, U.S. Department of Agriculture, and more than 3,000 state and local governments are charged with protecting consumers from these risks, but their efforts often are fragmented and uncoordinated.

[Click here for more of the press release, the report, a video, and an accompanying interview]

These Top-10 pathogen-food combinations cause the greatest burden to the public health 

• Campylobacter in Poultry costs $1.3 billion and causes a loss of 9500 QALYs (Quality Adjusted Life Years)
• ToxoplaSma in Pork costs $1.2 billion and causes a loss of 4500 QALYs
• LiSteria in Deli Meats costs $1.1 billion and causes a loss of 4000 QALYs
• Salmonella in Poultry costs $700 million and causes a loss of 3600 QALYs
• LiSteria in Dairy Products costs $700 million and causes a loss of 2600 QALYs
• Salmonella in Complex Foods costs $600 million and causes a loss of 3200 QALYs
• NoroviruS in Complex Foods costs $900 million and causes a loss of 2300 QALYs
• Salmonella in Produce costs $500 million and causes a loss of 2800 QALYs
• ToxoplaSma in Beef costs $700 million and causes a loss of 2500 QALYs
• Salmonella in Eggs costs $400 million and causes a loss of 1900 QALYs

Related Articles

• 80% of chickens in local grocery stores test positive for pathogens (thenewstribune.com)
• Cross-contamination versus undercooking of poultry meat or eggs – which risks need to be managed first? (foodhygiene2010.wordpress.com)
• Food-borne diseases – the challenges of 20 years ago still persist while new ones continue to emerge (foodhygiene2010.wordpress.com)
• More Dollars Per Quality Adjusted Life Year (QALY) Versus Savings From Care Management: How Can The Studies Be Reconciled? (diseasemanagementcareblog.blogspot.com)
• A global view on effectiveness research (kevinmd.com)